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Article

The host range phenotype displayed by a Sindbis virus glycoprotein variant results from virion aggregation and retention on the surface of mosquito cells.

Journal of virology - 1 Dec 2000

Boehme K W, Popov V L, Heidner H W

Abstract excerpt

The Sindbis virus variant NE2G216 is a PE2-containing host range mutant that is growth restricted in cultured mosquito cells (C6/36) due to inefficient release of virions from this cell type. The maturation defect of NE2G216 has been linked to the structures of N-linked oligosaccharides synthesized by arthropod cells. Analysis of C6/36 cells infected with NE2G216 by transmission electron microscopy revealed the...

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Identifiers

PMID: 11070041
DOI: 10.1128/jvi.74.23.11398-11406.2000
PMCID: PMC113246

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