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Article

Computational analysis and molecular dynamics insights into deleterious SNPs of the HFE gene.

Journal of biomolecular structure & dynamics - 1 Jun 2026

Islam Md Sajedul, Tanha Tasnim Hosen, Zarin Nazia, Haque Shaila, Shiddiky Muhammad J A, Lam Alfred K, Gopalan Vinod

Abstract excerpt

Mutations in the HFE gene, especially non-synonymous single-nucleotide polymorphisms (nsSNPs), are strongly associated with hemochromatosis, an autosomal recessive disorder characterized by intracellular iron overload, a key feature of tumor development. This study examined the structural and functional effects of deleterious nsSNPs in the HFE gene using bioinformatics tools, gene interaction analyses, molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41277739
DOI: 10.1080/07391102.2025.2593504

Genes

HFE
B2M
HJV
TFR2
TFRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Computational analysis and molecular dynamics insights into deleterious SNPs of the HFE gene.PMID 41277739Read ↗

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