Article
Complete sequencing and messenger ribonucleic acid expression analysis of the MEN I gene in adrenal cancer.
The Journal of clinical endocrinology and metabolism - 1 Jan 2000
Schulte K M, Mengel M, Heinze M, Simon D, Scheuring S, Köhrer K, Röher H D
Abstract excerpt
Adrenal cancer is a rare sporadic disease that has also been observed in the context of multiple endocrine neoplasia type I (MEN I). Adrenal lesions occur in up to 40% of MEN I patients. Loss of heterozygosity of the 11q13 band harboring the menin gene has been reported in more than 50% of patients with adrenal cancer. Despite this high index of suspicion, former screening studies did not reveal mutations of the...
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