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Article

Clinicopathological, prognostic, and molecular differences between microsatellite-stable colorectal cancer patients aged ≤ 30 years and > 30 years.

BMC cancer - 29 May 2026

Wang Yuanyuan, Jing Yi, Yang Yidi, Zhang Bing, Chang Zhu, Wang Yawen, Zhang Yinping, Xia Qingxin

Abstract excerpt

BACKGROUND: The biological and clinical heterogeneity of younger patients with microsatellite stable (MSS)/proficient mismatch repair (pMMR) colorectal cancer (CRC) is largely unexplored. This retrospective study compared the clinicopathological factors, prognosis, and molecular characteristics of MSS/pMMR CRC in patients younger and older than 30 years. METHODS: Overall, 191 younger (≤ 30 years old) and 892...

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PMID: 42210171
DOI: 10.1186/s12885-026-16262-1
PMCID: PMC13410863

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