Early Detection of Leptomeningeal Metastasis by PCR Examination of Tumor-derived K-ras DNA in Cerebrospinal Fluid

Abstract excerpt

Leptomeningeal metastasis (LMM) occurs in 3–8% of all cancer patients. Of the solid tumors, breast cancer, lung cancer, and malignant melanoma are the most common to metastasize to the leptomeninges (1). The prognosis for patients with LMM is poor: most individuals survive a median of only ∼4 months. Early diagnosis may improve the clinical response to radiotherapy and (intrathecal) chemotherapy, and may lead to...

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