Article
Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal metastasis in non-small-cell lung cancer patients harboring an active EGFR mutation following gefitinib therapy failure.
Respiratory investigation - 1 Jan 2016
Sasaki Shinichi, Yoshioka Yasuko, Ko Ryo, Katsura Yoko, Namba Yukiko, Shukuya Takehito, Kido Kenji, Iwakami Shinichiro, Tominaga Shigeru, Takahashi Kazuhisa
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been successfully used to treat patients with non-small cell lung cancer (NSCLC) harboring EGFR mutations. However, despite an initial excellent response, recurrence within one or two years is common. Diagnosis and treatment of leptomeningeal metastasis (LM), a form of NSCLC recurrence, remains particularly difficult. Here,...
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