Article
Detection of EGFR, KRAS and BRAF mutations in metastatic cells from cerebrospinal fluid.
Clinical chemistry and laboratory medicine - 25 Apr 2018
Frankel Diane, Nanni-Metellus Isabelle, Robaglia-Schlupp Andrée, Tomasini Pascale, Guinde Julien, Barlesi Fabrice, Astoul Philippe, Ouafik L'Houcine, Amatore Florent, Secq Véronique, Kaspi Elise, Roll Patrice
Abstract excerpt
BACKGROUND: In lung adenocarcinoma, molecular profiling of actionable genes has become essential to set up targeted therapies. However, the feasibility and the relevance of molecular profiling from the cerebrospinal fluid (CSF) in the context of meningeal metastasis have been poorly assessed. METHODS: We selected patients with stage IV lung adenocarcinoma harbouring metastatic cells in the CSF after cytological...
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