Article
Detection of epithelial growth factor receptor mutations in cerebrospinal fluid from patients with lung adenocarcinoma suspected of neoplastic meningitis.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2011
Shingyoji Masato, Kageyama Hajime, Sakaida Tsukasa, Nakajima Takahiro, Matsui Yukiko, Itakura Meiji, Iuchi Toshihiko, Yokoi Sana, Kimura Hideki, Iizasa Toshihiko
Abstract excerpt
BACKGROUND: Neoplastic meningitis (NM) is a devastating neurological complication of cancer that needs to be diagnosed in the early stages of disease. Polymerase chain reaction detection of epithelial growth factor receptor (EGFR) mutations in cerebrospinal fluid (CSF), which are predictive markers for EGFR tyrosine kinase inhibitor therapy in lung cancer, might be important to diagnose and to treat NM in...
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