Article
The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.
The Journal of biological chemistry - 7 Jan 2000
Webster K, Parish J, Pandya M, Stern P L, Clarke A R, Gaston K
Abstract excerpt
The human papillomavirus (HPV) E2 protein regulates viral gene expression and is also required for viral replication. HPV-transformed cells often contain chromosomally integrated copies of the HPV genome in which the viral E2 gene is disrupted. We have shown previously that re-expression of the HPV 16 E2 protein in HPV 16-transformed cells results in cell death via apoptosis. Here we show that the HPV 16 E2...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.