The induction of skeletal muscle hypertrophy by a ski transgene is promoter-dependent.

doi:10.1016/s0378-1119(99)00461-8

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Article

The induction of skeletal muscle hypertrophy by a ski transgene is promoter-dependent.

Gene - 4 Jan 2000

Sutrave P, Leferovich J M, Kelly A M, Hughes S H

Abstract excerpt

The chicken c-ski gene expresses at least three alternatively spliced messages. Transgenic mice expressing proteins from cDNA corresponding to two of these messages (FB27 and FB29) under the control of a murine sarcoma virus (MSV) long terminal repeat (LTR) express the transgene in skeletal muscle and develop a muscular phenotype. Both a biologically active form of c-ski and the MSV LTR are required for the...

Topics

Animals
Cloning, Molecular
DNA, Complementary
DNA-Binding Proteins
Hypertrophy
Mice
Mice, Transgenic
Models, Genetic
Muscle, Skeletal
Myosin Heavy Chains
Phenotype
Promoter Regions, Genetic
Proto-Oncogene Proteins
Ribonucleases
Sarcoma Viruses, Murine
Terminal Repeat Sequences
Tissue Distribution

Source

Open in PubMed

Identifiers

PMID: 10607904
DOI: 10.1016/s0378-1119(99)00461-8

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