Article
Immune modulation in pemphigus vulgaris: role of CD28 and IL-10.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2000
Toto P, Feliciani C, Amerio P, Suzuki H, Wang B, Shivji G M, Woodley D, Sauder D N
Abstract excerpt
Pemphigus vulgaris (PV) is an autoimmune bullous skin disease characterized by Abs to the desmosomal cadherin desmoglein-3. Although the autoantibodies have been shown to be pathogenic, the role of the cellular immune system in the pathology of pemphigus-induced acantholysis is unclear. To further delineate the potential role of T cell-signaling pathways in the pathogenesis of PV, we performed passive transfer...
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