Article
Potential gain in efficiency and power to detect gene-environment interactions by matching in case-control studies.
Genetic epidemiology - 1 Jan 2000
Stürmer T, Brenner H
Abstract excerpt
BACKGROUND: There is growing interest in interactions between genetic and environmental risk factors of disease, but adequate power to detect such interactions in epidemiologic studies is of concern. The aim of this paper is to quantify the effect of matching on the efficiency of estimation and power to detect gene-environment interactions in case-control studies. METHODS: Starting from an empirical example in...
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