Potential gain in precision and power by matching on strong risk factors in case-control studies: the example of laryngeal cancer.

Abstract excerpt

BACKGROUND: To increase the precision and power of case-control studies, controls are often matched on age and sex, but rarely on other known risk factors. Expensive tests of genetic susceptibility in a case-control study of laryngeal cancer made us examine the effect of matching for smoking and alcohol consumption on the power and potential size reduction of the required control sample. METHODS: According to...

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