Gene conversion can create new MHC alleles.

doi:10.1111/j.1600-065x.1999.tb01400.x

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Article

Gene conversion can create new MHC alleles.

Immunological reviews - 1 Feb 1999

Högstrand K, Böhme J

Abstract excerpt

It is possible to measure gene conversion of MHC genes with the help of a semi-nested PCR assay. Several considerations are of utmost importance when such an assay is set up. Using this assay, we have found that gene conversion occurs in MHC class II genes in mouse sperm, but not in somatic cells tested. Although this gene conversion occurs in germline cells, it is already completed in spermatogonia, and...

Topics

Alleles
Animals
Base Sequence
Gene Conversion
Humans
Major Histocompatibility Complex
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 10319269
DOI: 10.1111/j.1600-065x.1999.tb01400.x

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