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Article

Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster.

The Journal of cell biology - 13 Dec 1999

Matthies H J, Messina L G, Namba R, Greer K J, Walker M Y, Hawley R S

Abstract excerpt

Drosophila melanogaster oocytes heterozygous for mutations in the alpha-tubulin 67C gene (alphatub67C) display defects in centromere positioning during prometaphase of meiosis I. The centromeres do not migrate to the poleward edges of the chromatin mass, and the chromatin fails to stretch during spindle lengthening. These results suggest that the poleward forces acting at the kinetochore are compromised in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10601329
DOI: 10.1083/jcb.147.6.1137
PMCID: PMC2168102

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Source receipt: pubmed, retrieved 7 Sept 2026.

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