The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.

doi:10.1007/s00438-005-1109-x

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Article

The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.

Molecular genetics and genomics : MGG - 1 Jun 2005

Venkei Zsolt, Szabad János

Abstract excerpt

The dominant-negative female-sterile Kavar(D) mutations and their revertant kavar(r) alleles identify the alphaTubulin67C gene of Drosophila melanogaster, which codes for the maternally provided alpha-tubulin(4) isoform. The mutations result in the formation of monopolar, collapsed spindles (each with two nearby centrosomes, a tassel of microtubules and overcondensed chromosomes), thus revealing a novel function...

Topics

Alleles
Animals
Chromosome Mapping
Drosophila melanogaster
Female
Genes, Dominant
Immunohistochemistry
Mutation
Protein Isoforms
Spindle Apparatus
Transgenes
Tubulin

Source

Open in PubMed

Identifiers

PMID: 15864652
DOI: 10.1007/s00438-005-1109-x

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