Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IL-4 receptor alpha-chain variant Q576R is strongly associated with decreased kidney allograft survival.

Tissue antigens - 1 Nov 1999

Hackstein H, Klüter H, Fricke L, Hoyer J, Bein G

Abstract excerpt

The involvement of the interleukin-4 (IL-4) pathway in B-lymphocyte activation and induction of a T helper 2 (Th2) cell response prompted us to investigate the influence of a recently described gain-of function mutation in the IL-4 receptor alpha-chain gene (IL-4R alpha; CD 124) on renal allograft survival. We developed a genotyping assay for the IL-4R alpha variant Q576R and investigated 203 renal transplant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Graft Rejection
Share to Graft Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Receptors, Interleukin-4

Share to Transplantation, Homologous

Share to Transplantation Immunology

Source

Identifiers

PMID: 10599886
DOI: 10.1034/j.1399-0039.1999.540504.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IL-4 receptor alpha-chain variant Q576R is strongly associated with decreased kidney allograft survival.PMID 10599886Read ↗

TNF-alpha, IL-6, IFN-gamma, and IL-10 gene expression polymorphisms and the IL-4 receptor alpha-chain variant Q576R: effects on renal allograft outcome.Semantic proximity Read ↗

Association of CTLA-4 gene polymorphism with end-stage renal disease and renal allograft outcome.Semantic proximity Read ↗

Association Interleukin-4 and Interleukin-4 Receptor Gene Polymorphism and Acute Rejection and Graft Dysfunction After Kidney Transplantation.Semantic proximity Read ↗

Cooperative influence of the interleukin-6 promoter polymorphisms -597, -572 and -174 on long-term kidney allograft survival.Semantic proximity Read ↗

Study of the cytokine polymorphisms in correlation to rejection and graft survival in renal allograft donors and recipients from a homogenous Saudi population.Semantic proximity Read ↗

A Monocyte chemoattractant protein-1 (MCP-1) polymorphism and outcome after renal transplantation.Semantic proximity Read ↗

Definition of human interleukin-4 receptor alpha chain haplotypes and allelic association with atopy markers.Semantic proximity Read ↗

Interleukin-4-receptor alpha gene polymorphism and the risk of renal cell carcinoma in a South Indian population.Semantic proximity Read ↗

Impact of donor and recipient cytokine genotypes on renal allograft outcome.Semantic proximity Read ↗

The influence of CTLA-4 gene polymorphism on long-term kidney allograft function in Caucasian recipients.Semantic proximity Read ↗

Fc-gamma receptor 3A polymorphism predicts the incidence of urinary tract infection in kidney-transplant recipients.Semantic proximity Read ↗

An interleukin 6-based genetic risk score strengthened with interleukin 10 polymorphisms associated with long-term kidney allograft outcomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.