Article
Screening for MEN1 mutations in patients with atypical endocrine neoplasia.
Surgery - 1 Dec 1999
Dackiw A P, Cote G J, Fleming J B, Schultz P N, Stanford P, Vassilopoulou-Sellin R, Evans D B, Gagel R F, Lee J E
Abstract excerpt
BACKGROUND: Most patients from typical multiple endocrine neoplasia type 1 (MEN1) kindreds harbor mutations in the MEN-1 gene, MEN1. We hypothesized that some patients with atypical endocrine neoplasia would also have mutations in MEN1. METHODS: DNA sequencing analysis of mutations in the coding region of MEN1 was performed with genomic DNA obtained from peripheral blood lymphocytes in a total of 21 patients who...
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