A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region of the rat proteinase alpha1-inhibitor 3 variant I gene.

Abstract excerpt

As a first step towards understanding the mechanism underlying the differential gene expression of the two variants of the rat proteinase-inhibitor alpha1-inhibitor 3 (alpha1-I3) corresponding genomic clones were isolated. The 100% similarity between the sequence of one genomic clone and that of the alpha1-13 variant I cDNA strongly suggested that its 5'-sequence represented the upstream region of the...

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