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Article

Delay of muscle degeneration and necrosis in mdx mice by calpain inhibition

1 Jan 2000

Abstract excerpt

Inhibition of muscle degeneration by the tripeptide calpain inhibitor, leupeptin, was tested in vivo in a dystrophin-deficient mdx murine model. In a short-term control study, intramuscular administration of leupeptin for 30 days inhibited muscle degeneration as assessed by histologic analysis. Calpain inhibition could be correlated with retention of myofiber size and our results suggest that this may be a...

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Identifiers

PMID: 10590413
DOI: 10.1002/(sici)1097-4598(200001)23:1<106::aid-mus14>3.0.co;2-d

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