Article
Leupeptin-based inhibitors do not improve the mdx phenotype.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Nov 2010
Selsby Joshua, Pendrak Klara, Zadel Monica, Tian Zuozhen, Pham Jennifer, Carver Ted, Acosta Pedro, Barton Elisabeth, Sweeney H Lee
Abstract excerpt
Calpain activation has been implicated in the disease pathology of Duchenne muscular dystrophy. Inhibition of calpain has been proposed as a promising therapeutic target, which could lessen the protein degradation and prevent progressive fibrosis. At the same time, there are conflicting reports a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.