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Article

Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathology

27 Sept 2002

Abstract excerpt

Reduced sarcolemmal integrity in dystrophin-deficient muscles of mdx mice and Duchenne muscular dystrophy (DMD) patients has been reported to result in altered calcium homeostasis. Previous studies have shown a correlative relationship between calcium-dependent protease (calpain) activity in dystrophic muscle and muscle necrosis, but have not tested whether calpain activation precedes cell death or is a...

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PMID: 12354790
DOI: 10.1093/hmg/11.21.2645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of a calpastatin transgene in mdx muscle reduces dystrophic pathologyPMID 12354790Read ↗

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