Article
L-arginine improves dystrophic phenotype in mdx mice.
Neurobiology of disease - 1 Oct 2005
Voisin Vincent, Sébrié Catherine, Matecki Stéfan, Yu Hua, Gillet Brigitte, Ramonatxo Michèle, Israël Maurice, De la Porte Sabine
Abstract excerpt
A possible treatment for Duchenne muscular dystrophies would be to compensate for dystrophin loss by increasing the expression of utrophin, another cytoskeletal protein of the muscle membrane. We previously found that L-arginine, the substrate for nitric oxide synthase, significantly increased utrophin level in muscle and targeted it to the sarcolemma. Here, we have addressed the expected benefit in the mdx mice....
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