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Article

Integrin αVβ3as a Target for Blocking HIV-1 Tat-Induced Endothelial Cell Activation In Vitro and Angiogenesis In Vivo

16 Sept 2005

Abstract excerpt

OBJECTIVE: The transactivating factor (Tat) of HIV-1 binds to alphavbeta3 integrin present on endothelial cells contributing to neovascularization. Here, we investigated the biological consequences of Tat/alphavbeta3 interaction and the antagonist effect of an Arg-Gly-Asp (RGD)-based peptidomimetic. METHODS AND RESULTS: Binding of Tat to endothelial alphavbeta3 triggers focal adhesion kinase and nuclear...

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Identifiers

PMID: 16166568
DOI: 10.1161/01.atv.0000186182.14908.7b

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