Article
DAR, a new RhD variant involving exons 4, 5, and 7, often in linkage with ceAR, a new Rhce variant frequently found in African blacks.
Blood - 15 Dec 1999
Hemker M B, Ligthart P C, Berger L, van Rhenen D J, van der Schoot C E, Wijk P A
Abstract excerpt
The highly polymorphic Rh system is encoded by 2 homologous genes RHD and RHCE. Gene rearrangements, deletions, or point mutations may cause partial D and CE antigens. In this study, a new RHD variant, DAR, and a new RHCE variant, ceAR, are described in 4 Dutch African Blacks. Serologically, DAR showed weaker reactions with a monoclonal antibody and polyclonal antiserum against D. The DAR phenotype was...
Topics
- Africa
- Alleles
- Black People
- Exons
- Gene Rearrangement
- Humans
- Rh-Hr Blood-Group System
- Sequence Analysis, DNA