Article
A D+ blood donor with a novel RHD*D-CE(5-6)-D gene variant exhibits the low-frequency antigen RH23 (D(W) ) characteristic of the partial DVa phenotype.
Transfusion - 1 Sept 2016
Lopez Genghis H, McGowan Eunike C, McGrath Kelli A, Abaca-Cleopas Maria E, Schoeman Elizna M, Millard Glenda M, O'Brien Helen, Liew Yew-Wah, Flower Robert L, Hyland Catherine A
Abstract excerpt
BACKGROUND: Blood donors whose red blood cells (RBCs) exhibit a partial RhD phenotype, lacking some D epitopes, present as D+ in routine screening. Such phenotypes can exhibit low-frequency antigens (LFAs) of clinical significance. The aim of this study was to describe the serologic and genetic profile for a blood donor with an apparent D+ phenotype carrying a variant RHD gene where D Exons 5 and 6 are replaced...
Topics
- Alleles
- Blood Donors
- Epitopes
- Erythrocytes
- Exons
- Gene Frequency
- Humans
- Phenotype
- Rh-Hr Blood-Group System