Article
Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice.
Nature genetics - 1 Nov 1995
Adlkofer K, Martini R, Aguzzi A, Zielasek J, Toyka K V, Suter U
Abstract excerpt
Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral neuropathies such as Charcot-Marie-Tooth disease type 1A. We now demonstrate that mice devoid of Pmp22 are retarded i...
Topics
- Animals
- Axons
- Demyelinating Diseases
- Disease Models, Animal
- Gene Dosage
- Hereditary Sensory and Motor Neuropathy
- Mice
- Mice, Transgenic
- Muscles
- Mutation
- Myelin Proteins
- Myelin Sheath
- Neural Conduction
- Peripheral Nervous System Diseases
- Seizures
- Tremor