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Article

Analysis of Tyr to Phe and fa/fa leptin receptor mutations in the PC12 cell line.

European cytokine network - 1 Dec 1999

Eyckerman S, Waelput W, Verhee A, Broekaert D, Vandekerckhove J, Tavernier J

Abstract excerpt

Weight regulation through body-fat content and energy homeostasis, is regulated mainly through the actions of leptin. Herein, we analyse the effect of mutations in the mouse leptin receptor using the PC12 pheochromocytoma cell line as a model system. Both the induction of pancreatitis associated protein 1 and metallothionein-II, two leptin regulated genes in PC12, was evaluated. Tyr to Phe mutations in the...

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Share to Receptors, Leptin
Share to Acute-Phase Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immediate-Early

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PMID: 10586122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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