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Article

Determinants of O(6)-alkylguanine-DNA alkyltransferase activity in normal and tumour tissue from human colon and rectum.

International journal of cancer - 1 Jan 2000

Povey A C, Hall C N, Cooper D P, O'Connor P J, Margison G P

Abstract excerpt

O(6)-Alkylguanine-DNA-alkyltransferase (ATase) is an important modulator of alkylating agent-induced toxicity and carcinogenicity, but those factors which influence the expression of this repair protein in human tissues are poorly characterised. In this study, we have determined ATase levels in macroscopically normal and tumour tissues from 76 individuals with benign or malignant colorectal disease. All tissue...

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Source

Identifiers

PMID: 10585585
DOI: 10.1002/(sici)1097-0215(20000101)85:1<68::aid-ijc12>3.0.co;2-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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