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Article

Longitudinal variation in O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum.

British journal of cancer - 15 Jul 2002

Lees N P, Harrison K L, Hill E, Hall C N, Margison G P, Povey A C

Abstract excerpt

In a systematic study of O(6)-alkylguanine DNA-alkyltransferase activity in the human colon and rectum, tumours were found to occur in regions of low activity. These results are consistent with the hypothesis that O(6)-alkylguanine DNA-alkyltransferase levels and alkylating agent exposure may be important determinants of large bowel tumorigenesis.

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Source

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Identifiers

PMID: 12107837
DOI: 10.1038/sj.bjc.6600455
PMCID: PMC2376118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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