Article
Prevalence of the mutation C677 --> T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil.
American journal of medical genetics - 24 Jul 1998
Arruda V R, Siqueira L H, Gonçalves M S, von Zuben P M, Soares M C, Menezes R, Annichino-Bizzacchi J M, Costa F F
Abstract excerpt
Vascular disease is a serious public health problem in the industrialized world, and is a frequent cause of death among the adult population of Brazil. Mild hyperhomocysteinemia has been identified as a risk factor for arterial disease, venous thrombosis, and neural tube defects. Individuals homozygous for the thermolabile variant of methylenetetrahydrofolate reductase (MTHFR-T) are found in 5-15% of the general...
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