Article
Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
Antimicrobial agents and chemotherapy - 1 Dec 1999
Westbrock-Wadman S, Sherman D R, Hickey M J, Coulter S N, Zhu Y Q, Warrener P, Nguyen L Y, Shawar R M, Folger K R, Stover C K
Abstract excerpt
Pseudomonas aeruginosa can employ many distinct mechanisms of resistance to aminoglycoside antibiotics; however, in cystic fibrosis patients, more than 90% of aminoglycoside-resistant P. aeruginosa isolates are of the impermeability phenotype. The precise molecular mechanisms that produce aminoglycoside impermeability-type resistance are yet to be elucidated. A subtractive hybridization technique was used to...
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