Article
Mechanism of amikacin resistance in Pseudomonas aeruginosa isolates from patients with cystic fibrosis.
Diagnostic microbiology and infectious disease - 1 Aug 1995
Hurley J C, Miller G H, Smith A L
Abstract excerpt
We studied 27 amikacin-resistant isolates of Pseudomonas aeruginosa from patients with cystic fibrosis to determine the mechanism of antibiotic resistance. The absence of aminoglycoside-modifying enzymes (AMEs) in these isolates was inferred from the failure of DNA probes for 16 candidate AMEs to hybridize with DNA harvested from these isolates and, in addition, the uniform reduction in susceptibility to a panel...
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