Article
A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.
Biochemical and biophysical research communications - 9 Dec 1999
Mitsui K, Nakanishi M, Ohtsuka S, Norwood T H, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M
Abstract excerpt
Cyclin E-Cdk2 is an evolutionary conserved cyclin-dependent kinase (CDK) complex that drives the G1 to S phase transition of the cell cycle. A novel cDNA encoding a HECT family protein also containing RCC1-like repeats was isolated by a yeast two-hybrid screening using both cyclin E and its inhibitor p21. The protein product of this cDNA, Ceb1, interacts with various cyclin subunits of CDKs in mammalian cells....
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