Article
The RCC1 superfamily: from genes, to function, to disease.
Biochimica et biophysica acta - 1 Aug 2008
Hadjebi Ouadah, Casas-Terradellas Eduard, Garcia-Gonzalo Francesc R, Rosa Jose Luis
Abstract excerpt
The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51-68 amino acid residues, which were later shown to adopt a seven-bladed beta-propeller fold. Since the initial identification of RCC1, a number of proteins have been discovered that contain one or...
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