Article
Alternative splicing of human cyclin E.
Journal of cell science - 1 Feb 1994
Sewing A, Rönicke V, Bürger C, Funk M, Müller R
Abstract excerpt
Cyclin E is a regulatory subunit of the cdc2-related protein kinase cdk2, which is activated shortly before S-phase entry, thus defining it as a G1 cyclin. We report here the existence of a 43 kDa splice variant of human cyclin E, termed cyclin Es, which lacks 49 amino acids within the cyclin box compared to the known 48 kDa cyclin E. Cyclin Es is expressed at approximately 1/10 of the level of full-length cyclin...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Base Sequence
- CDC2-CDC28 Kinases
- Cell Line
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinases
- Cyclins
- DNA Primers
- Humans
- Molecular Sequence Data
- Mutation