Article

Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells

2022-11-01

Abstract excerpt

The mechanisms leading to adrenal cortex development and steroid synthesis in humans remain poorly understood due to the paucity of model systems. Herein, we faithfully recapitulate human fetal adrenal cortex specification processes through stepwise induction of human induced pluripotent stem cells through posterior intermediate mesoderm-like and adrenal progenitor-like states to ultimately generate fetal zone adr...

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Literature Corpus work: 7ca7ed95-ff8c-54d9-9852-53db8e6991e3
DOI: 10.1101/2022.10.31.514433

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