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Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages

1 Dec 2009

Abstract excerpt

The adrenal cortex is a critical steroidogenic endocrine tissue, generated at least in part from the coelomic epithelium of the urogenital ridge. Neither the intercellular signals that regulate cortical development and maintenance nor the lineage relationships within the adrenal are well defined. We have explored adrenal Shh activity and found that Shh is expressed in relatively undifferentiated steroidogenic...

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PMID: 19955443
DOI: 10.1073/pnas.0909471106

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