Article
Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians.
Metabolism: clinical and experimental - 1 Mar 2001
Ye W Z, Dubois-Laforgue D, Bellanné-Chantelot C, Timsit J, Velho G
Abstract excerpt
Electrophoretic variants of the vitamin D-binding protein (DBP) have been reported to be associated with type 2 diabetes mellitus (DM) or with prediabetic phenotypes in several non-Caucasian populations. Two frequent missense polymorphisms at codons 416 (Asp --> Glu) and 420 (Thr --> Lys) are the genetic basis for the 3 common electrophoretic variants of DBP (Gc1F, Gc1S, and Gc2) and the resulting circulating...
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