Article
Common polymorphism in a highly variable region upstream of the human lactase gene affects DNA-protein interactions.
European journal of human genetics : EJHG - 1 Jan 2000
Hollox E J, Poulter M, Wang Y, Krause A, Swallow D M
Abstract excerpt
In most mammals lactase activity declines after weaning when lactose is no longer part of the diet, but in many humans lactase activity persists into adult life. The difference responsible for this phenotypic polymorphism has been shown to be cis-acting to the lactase gene. The causal sequence difference has not been found so far, but a number of polymorphic sites have been found within and near to the lactase...
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