Article
European lactase persistence genotype shows evidence of association with increase in body mass index.
Human molecular genetics - 15 Mar 2010
Kettunen Johannes, Silander Kaisa, Saarela Olli, Amin Najaf, Müller Martina, Timpson Nicholas, Surakka Ida, Ripatti Samuli, Laitinen Jaana, Hartikainen Anna-Liisa, Pouta Anneli, Lahermo Päivi, Anttila Verneri, Männistö Satu, Jula Antti, Virtamo Jarmo, Salomaa Veikko, Lehtimäki Terho, Raitakari Olli, Gieger Christian, Wichmann Erich H, Van Duijn Cornelia M, Smith George Davey, McCarthy Mark I, Järvelin Marjo-Riitta, Perola Markus, Peltonen Leena
Abstract excerpt
The global prevalence of obesity has increased significantly in recent decades, mainly due to excess calorie intake and increasingly sedentary lifestyle. Here, we test the association between obesity measured by body mass index (BMI) and one of the best-known genetic variants showing strong selective pressure: the functional variant in the cis-regulatory element of the lactase gene. We tested this variant since...
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