Article
The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity.
Human genetics - 1 Oct 2011
Jensen Tine G K, Liebert Anke, Lewinsky Rikke, Swallow Dallas M, Olsen Jørgen, Troelsen Jesper T
Abstract excerpt
In most people worldwide intestinal lactase expression declines in childhood. In many others, particularly in Europeans, lactase expression persists into adult life. The lactase persistence phenotype is in Europe associated with the -13910*T single nucleotide variant located 13,910 bp upstream the lactase gene in an enhancer region that affects lactase promoter activity. This variant falls in an Oct-1 binding...
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