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Article

Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis.

Biochemistry - 26 Oct 1999

Williams N L, Maxwell A

Abstract excerpt

Supercoiling by DNA gyrase involves the passage of one segment of double-stranded DNA through another. This requires a DNA duplex to be cleaved and the broken ends separated by at least 20 A. This is accomplished by the opening of a dimer interface, termed the DNA gate, which is covalently attached to the broken ends of the DNA. After strand passage, the DNA gate closes allowing the reunion of the broken ends. We...

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Identifiers

PMID: 10571989
DOI: 10.1021/bi991478m

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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