The detection of somatic mutations of thyrotropin receptor gene in fine needle biopsy samples from thyroid nodules.

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Article

The detection of somatic mutations of thyrotropin receptor gene in fine needle biopsy samples from thyroid nodules.

Endocrine regulations - 1 Sept 1999

Syrenicz A, Kurzawski G, Ciechanowicz A

Abstract excerpt

OBJECTIVE: To evaluate the detection possibility of TSH receptor gene mutation within the third cytoplasmic loop and the sixth transmembrane domain in the cytological material obtained by means of fine needle biopsy of autonomous and non-autonomous nodules. METHODS: The study has been carried out in 16 women with goitre showing no clinical signs of hyperthyroidism. According to the thyroid scintigraphy and serum...

Topics

Adenine
Adult
Base Sequence
Biopsy, Needle
Cytosine
DNA
DNA Mutational Analysis
Female
Goiter
Heterozygote
Humans
Middle Aged
Mutation
Polymerase Chain Reaction
Proline
Receptors, Thyrotropin
Threonine
Thyroid Nodule

Source

Open in PubMed

Identifiers

PMID: 10571960

Provenance

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