Article
Possible involvement of matrix metalloproteinase-9 in Langerhans cell migration and maturation.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1999
Kobayashi Y, Matsumoto M, Kotani M, Makino T
Abstract excerpt
Epidermal Langerhans cells (LC) are potent dendritic cells in the induction of primary T cell-mediated immune responses in the skin. They capture foreign Ags and migrate to regional lymph nodes to carry and present these Ags to naive T cells. We investigated the role of matrix metalloproteinase-9 (MMP-9) in LC migration using an anti-MMP-9 mAb. Intradermal injection of anti-MMP-9 mAb before rhodamine B or...
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