Article
Subcellular localization patterns and their relationship to photodynamic activity of pyropheophorbide-a derivatives.
Photochemistry and photobiology - 1 Nov 1999
MacDonald I J, Morgan J, Bellnier D A, Paszkiewicz G M, Whitaker J E, Litchfield D J, Dougherty T J
Abstract excerpt
To determine if subcellular localization is important to photodynamic therapy (PDT) efficacy, an in vitro fluorescence microscopy study was conducted with a congeneric series of pyropheophorbide-a derivatives in human pharyngeal squamous cell carcinoma (FaDu) cells and murine radiation-induced fibrosarcoma (RIF) mutant cells. In the FaDu cells the octyl, decyl and dodecyl ether derivatives localized to the...
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