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Bio-distribution and subcellular localization of Hypericin and its role in PDT induced apoptosis in cancer cells

1 Sept 2002

Abstract excerpt

The development of new-generation photosensitizers to improve photodynamic therapy (PDT) and photodynamic diagnosis (PDD) is an area of extensive research. One such compound that has been studied in our group is Hypericin (HY). To study the mechanism of action we have investigated uptake, intracellular localization, cell phototoxicity and morphological changes especially to ultrastructures following photodynamic...

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PMID: 12168096
DOI: 10.3892/ijo.21.3.531

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