Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

On-line high-performance liquid chromatography/mass spectrometric investigation of amyloid-beta peptide variants found in Alzheimer's disease.

Rapid communications in mass spectrometry : RCM - 1 Jan 1999

Thompson A J, Lim T K, Barrow C J

Abstract excerpt

Abeta peptides are the major components of amyloid deposits in Alzheimer's disease. The presence of N-terminally truncated Abeta variants in amyloid may be a critical factor in Alzheimer's disease pathogenesis. These Abeta variants are less soluble and more amyloidogenic than full-length Abeta, making their separation, purification and identification difficult. High-performance liquid chromatography (HPLC) at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amino Acid Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Chromatography, High Pressure Liquid

Share to Mass Spectrometry

Share to Molecular Sequence Data

Share to Peptide Fragments

Share to Peptides

Source

Identifiers

PMID: 10567933
DOI: 10.1002/(SICI)1097-0231(19991215)13:23<2348::AID-RCM797>3.0.CO;2-J

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

On-line high-performance liquid chromatography/mass spectrometric investigation of amyloid-beta peptide variants found in Alzheimer's disease.PMID 10567933Read ↗

Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease.Semantic proximity Read ↗

New plasma LC-MS/MS assays for the quantitation of beta-amyloid peptides and identification of apolipoprotein E proteoforms for Alzheimer’s disease risk assessmentSemantic proximity Read ↗

Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides.Semantic proximity Read ↗

Understanding Aβ25-35 peptide altered exosomal proteome and associated pathways linked with the Alzheimer’s disease pathogenesis using human neuroblastoma SH-SY5Y CellsSemantic proximity Read ↗

Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assay.Semantic proximity Read ↗

Serum amyloid beta peptides in patients with dementia and age-matched non-demented controls as detected by surface-enhanced laser desorption ionisation-time of flight mass spectrometry (SELDI-TOF MS).Semantic proximity Read ↗

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.Semantic proximity Read ↗

Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.Semantic proximity Read ↗

The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates.Semantic proximity Read ↗

Characterization of amyloid beta peptides from brain extracts of transgenic mice overexpressing the London mutant of human amyloid precursor protein.Semantic proximity Read ↗

Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease.Semantic proximity Read ↗

Data Independent Acquisition to Inform the Development of Targeted Proteomics Assays Using a Triple Quadrupole Mass SpectrometerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.