Article
Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life.
The Journal of clinical endocrinology and metabolism - 1 Nov 1999
Aguiar-Oliveira M H, Gill M S, de A Barretto E S, Alcântara M R, Miraki-Moud F, Menezes C A, Souza A H, Martinelli C E, Pereira F A, Salvatori R, Levine M A, Shalet S M, Camacho-Hubner C, Clayton P E
Abstract excerpt
Measurement of the insulin-like growth factors (IGFs) and their binding proteins has become commonplace in the indirect assessment of the integrity of the GH axis. However, the relative effect of GH deficiency (GHD) on each component of the IGF axis and the merit of any one parameter as a diagnostic test have not been defined in a homogeneous population across all ages. We therefore measured IGF-I, IGF-II,...
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