Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A non-cytotoxic herpes simplex virus vector which expresses Cre recombinase directs efficient site specific recombination.

Virus research - 1 Dec 1999

Rinaldi A, Marshall K R, Preston C M

Abstract excerpt

The coding sequences for the bacteriophage P1 recombinase Cre were cloned into the genome of a herpes simplex virus type 1 (HSV-1) mutant which is severely impaired for the synthesis of immediate early (IE) proteins. The resulting recombinant, virus in1372, expressed functional Cre which mediated the excision in trans of loxP-flanked sequences located in the HSV-1 genome, both in tissue culture cells and in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to Cricetinae
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Herpesvirus 1, Human

Share to Integrases

Share to Neurons, Afferent

Share to Vero Cells

Share to Viral Proteins

Source

Identifiers

PMID: 10564749
DOI: 10.1016/s0168-1702(99)00102-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A non-cytotoxic herpes simplex virus vector which expresses Cre recombinase directs efficient site specific recombination.PMID 10564749Read ↗

A cell-free recombination system for site-specific integration of multigenic shuttle plasmids into the herpes simplex virus type 1 genome.Semantic proximity Read ↗

Multiple applications for replication-defective herpes simplex virus vectors.Semantic proximity Read ↗

Gene Delivery Using Herpes Simplex Virus VectorsSemantic proximity Read ↗

In vivo disruption of latent HSV by designer endonuclease therapySemantic proximity Read ↗

In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing EndonucleaseSemantic proximity Read ↗

HSV-1-Derived Recombinant and Amplicon Vectors for Gene Transfer and Gene TherapySemantic proximity Read ↗

A historical analysis of herpes simplex virus promoter activation in vivo reveals distinct populations of latently infected neuronesSemantic proximity Read ↗

Gene Transfer to Neurons Using Herpes Simplex Virus-Based VectorsSemantic proximity Read ↗

Efficient delivery of RNA Interference to peripheral neurons in vivo using herpes simplex virusSemantic proximity Read ↗

Genomic targeting of a bicistronic DNA fragment by Cre-mediated site-specific recombination.Semantic proximity Read ↗

Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo.Semantic proximity Read ↗

Deletion of multiple immediate–early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neuronsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.